Gabapentin immediate-release (IR) is FDA approved to treat certain types of seizures and postherpetic neuralgia. It’s also used off-label for several conditions, such as alcohol use disorder, fibromyalgia, and anxiety. And it’s prescribed for other types of nerve pain, such as sciatica and nerve pain from diabetes.
Gabapentin is also available in two extended-release (ER) forms: Gralise and Horizant. Gralise is approved for postherpetic neuralgia. Horizant is approved for postherpetic neuralgia and restless leg syndrome.
Are there factors that can affect how long gabapentin takes to work?
Yes, several factors can affect how long it takes for gabapentin to work. They include:
- How quickly you reach your ideal dose: Your gabapentin dosage may be increased every few days. But if you have side effects from gabapentin, your prescriber may wait longer between dosage increases. This allows your body to get used to the medication. If your dose is increased more slowly, it may take longer to feel the medication’s full benefits.
- Other medications you take: Certain medications can interact with gabapentin, and some interactions may lead to lower levels of gabapentin in the body. For example, medications containing aluminum or magnesium can lower gabapentin absorption. Examples include magnesium oxide and Rolaids (calcium carbonate / magnesium hydroxide). It’s best to avoid taking gabapentin within 2 hours of taking these medications so gabapentin can achieve its full effect.
- Foods you eat: Taking gabapentin with high-protein foods may increase the amount of gabapentin your body absorbs. This may also affect how quickly gabapentin starts to work. You can take gabapentin IR with or without food. But you should take Horizant and Gralise with food for maximum absorption.